This directory includes several sample ISML models. For getting started with insilicoIDE (ISIDE), these sample models are prepared here. Users can load a model into ISIDE and can give a try to simulate it. The simulator provided by physiome.jp is called insilicoSim (ISSim) that is included in the package available at www.physiome.jp. Or users can convert a model into a C++ code and execute a binary file obtained by compiling the code. In this case users need a converter such as g++ and Visual C++ (for MS Windows). Models including morphology data and partial differential equations are also here. They are solved by FreeFEM++ application available at http://www.freefem.org/ff++/index.htm . So users need to install it before users try to simulate the models. Here are the following five subdirectories. 1. SimulateWithISSim 2. SimulateWithFreeFem 3. SimulateWithCpp 4. ShowMorphoDynamics 5. PythonScripts 1. SimulateWithISSim includes models that can be simulated by ISSim. The models can be loaded on insilicoIDE (ISIDE) and you can edit them as you want. Press Simulation > insilicoSim in the menu bar of ISIDE then the simulator is launched. See Readme in the SimulateWithISSim directory for more details. 2. SimulateWithFreeFem includes models involving morphology information and partial differential equations. The PDEs are solved on the morphology with finite element method. The models must be converted into FreeFEM++ format form File > Export menu. Then the converted file must be given to FreeFEM++ application. 3. SimulateWithCpp includes a model using template/instance scheme which is one of interesting feature of ISML specification. For example, when you want to create a 100 neurons which are basically the same with slight difference in static parameter values, then you do not need create each of them as an independent neuron. Instead, you just create one neuron, and define it as a template. Then you can create 100 instances of the template neuron. These 100 instances are basically the same with the template, but you can adjust some static parameters in each instance. ISIDE can convert a model including template/instance scheme, so users can simulate it by compiling the C++ code. Buy ISSim is not able yet to support the template/instance scheme and cannot simulate such model. ISIDE also does not yet support template/instance scheme and cannot display correctly and edit models including the scheme. 4. ShowMorphoDynamics includes a sample model including morphology data, time series data and a directory including morphology data. A model can be loaded on ISIDE. Users can see the morphological expression of the model by selecting "Show Morphology Data" in a context menu appearing by pressing a right mouse button on a module. The model also includes a time series data. If users select "Show Morpho-Dynamics" in the context menu, a movie will appear on the screen which is created using the morphology data and the timeseries data. The model is not for simulation by any means (ISSim, FreeFEM, C++). 5. PythonScripts includes several python scripts to create models. These scripts exemplify how to use python API. Users can execute these scripts on a terminal window like as follows: $ python ./sample/PyhtonScripts/make_N_coupled_hh.py Notice that the current directly must be the directly that includes initialize.py Then the script generates an ISML model in the current directly. The model can be loaded in ISIDE and simulated either by ISSim or by converting to C++.